The swine flu vaccine and Guillain-Barre syndrome

February, 1999
Report Number: 
546
Authors: 
D.A. Freedman and P.B. Stark
Citation: 
in Surveys on Solution Methods for Inverse Problems, Colton, D.,
Abstract: 

Epidemiologic methods were developed to prove general causation: identifying exposures that increase the risk of particular diseases. Courts often are more interested in specific causation: on balance of probabilities, was the plaintiff's disease caused by exposure to the agent in question? Some authorities have suggested that a relative risk greater than 2.0 meets the standard of proof for specific causation. Such a definite criterion is appealing, but there are difficulties. Bias and confounding are familiar problems; individual differences must be considered too. The issues are explored in the context of the swine flu vaccine and Guillain-Barre syndrome.

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