DNA and RNA Sequencing Local Sequence Assembly Reveals a High-Resolution Profile of Somatic Structural Variations in 97 Cancer Genomes

DNA and RNA Sequencing Local Sequence Assembly Reveals a High-Resolution Profile of Somatic Structural Variations in 97 Cancer Genomes

Statistics and Genomics Seminar
Apr 14, 2016, 04:00 PM - 05:00 PM | 1011 Evans Hall | Happening As Scheduled
Zhiping Weng, University of Massachusetts Medical School
Genomic structural variations (SVs) are pervasive in many types of cancers. Characterizing their underlying mechanisms and potential molecular consequences is crucial for understanding the basic biology of tumorigenesis. Here, we engineered a local assembly-based algorithm (laSV) that detects SVs with high accuracy from paired-end high-throughput genomic sequencing data and pinpoints their break-...