Mutation, Copy Number and LOH in Cancer Genomes via Next Generation Sequencing
Statistics and Genomics Seminar
Jan 20, 2011, 04:00 PM - 05:00 PM | 1011 Evans Hall | Happening As Scheduled
Dr. Peter M. Haverty, Genentech (Speaker)
Although previous studies have identified important common somatic mutations in lung cancers, they have primarily focused on a limited set of genes and have thus provided a constrained view of the mutational spectrum. Here we present the complete sequences of a primary lung tumour (60x coverage) and adjacent normal tissue (46x).
Comparing the two genomes, we identify a wide variety of somatic...