Coverage statistics for sequence census methods

April, 2010
Report Number: 
787
Authors: 
Steven N. Evans, Valerie Hower and Lior Pachter
Abstract: 

We study the shape of coverage functions resulting from the sequencing of random genome fragments, and show that they can be described by Galton-Watson trees. This extends standard analyses of shotgun sequencing that focus on coverage statistics at individual sites, and provides a null model for detecting deviations from random coverage in high-throughput sequence census based experiments such as ChIP-Seq.

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